According to the video, the game’s combat system has been heavily modified. There will be new weapons, the field of combat has been increased, and enemy AI has also been improved to react differently depending on scenarios. Examples given were enemies would jump over objects and if you shot them in the leg, they would even crawl on the floor.
One of BioWare’s goals was to increase the intensity from the original Mass Effect. There will be a darker story, new alien species, and a wide variety of worlds to explore. In relation to comments concerning keeping your save files from the first game, it will go much further than loading your character's personalised settings - characters who were killed in your play-through of the original won't appear in the sequel. In short, the story is kept in continuation with your choices.
We’ve embedded the video in this article for those who wish to view some in-game footage for themselves. Please be warned that it does contain spoilers that are relevant to the plot, but regardless, it’s safe to say fans are in for a wild ride.

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