Gunblade NY and LA Machineguns has been adapted from the original arcade machine games to make full use of the Wii controller. Whilst interacting and shooting on the streets of New York and Los Angeles the Wii ZapperTM compatibility provides even more immersion for the players. Gunblade NY and LA Machineguns Arcade Hits Pack also contains new features such as the Chain Combo System which enables even higher scores, and the Unlockable Weapon Toggle which uses game ranking to unlock hidden extras such as wide shot, rapid fire and heavy shot.

True to the original arcade games, Gunblade NY and LA Machineguns for Wii is set in the airspace above some of the United States' most well-known locations. Players will be able to combat android invaders in New York City with their Gunblade helicopter gunship or take their flying gunship to battle a new force of android enemies in some of America's most well known locales such as Los Angeles, Alcatraz, Yosemite and Las Vegas.